Background.Vitiligo is an acquired depigmentary skin disorder resulting fromautoimmune destruction of melanocytes. Regulatory\nT cells (Tregs), specifically CD4+CD25+ and Forkhead box P3+ (FoxP3+) Tregs, acquired notable attention because of their role in\na variety of autoimmune pathologies. Dysregulation of Tregs may be one of the factors that can break tolerance to melanocyte\nself-antigens and contribute to vitiligo pathogenesis. Methods. In order to sustain the role of Tregs in pathogenesis and disease\nactivity of vitiligo, surface markers for CD4+CD25+ and FoxP3+ peripheral Tregs were evaluated by flow cytometry in 80 Egyptian\npatients with nonsegmental vitiligo in addition to 60 healthy control subjects and correlated with clinical findings. Results. Vitiligo\npatients had significantly decreased numbers of both peripheral CD4+CD25+ and FoxP3+ T cells compared to control subjects\n(11.49% �± 8.58% of CD4+ T cells versus 21.20% �± 3.08%, and 1.09% �± 0.96% versus 1.44% �± 0.24%, resp.,
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